Suppr超能文献

[一种治疗I型糖尿病的有前景的替代方法。可植入式胰岛素泵]

[A promising alternative for the treatment of type I diabetes. The implantable insulin pump].

作者信息

Marescaux J, Vix M, Mutter D, Jeandidier N, Boivin S, Pinget M

机构信息

Service de Chirurgie digestive et endocrinienne, Les Hôpitaux Universitaires, Strasbourg.

出版信息

Chirurgie. 1993;119(9):579-84; discussion 584-5.

PMID:7729209
Abstract

Recent improvements in miniaturization of implantable pumps and the ability of their control by tele transmission allowed implantation of autonomous pumps which administer insulin into the peritoneal cavity. Fifty-six patients with diabetes mellitus underwent implantation of 66 pumps with a mean function life of 21.8 months per patient. No patient died to this day. Tolerance of implanted components was good. Morbidity was limited to local events, in this series 4 cutaneous erosions, two of them dictating final pump explantation. Dosages of mean global blood-sugar, pre- and post-prandial blood-sugar, and glycosylated hemoglobin were all lower versus dosages before implantation. Statistically significant difference was demonstrated regarding mean global blood-sugar. Frequency of sever hypoglycemia incidents (4 in our series) and of biological hypoglycemia (blood-sugar < 65 mg/100 ml) was decreased, representing major benefit of the technique. The patients well-being and quality of life were notably amended. Implantable insulin-pump may be offered as a treatment alternative to conventional insulin-therapy, especially in cases of diabetes which are difficult to balance and particularly in cases with frequent hypoglycemic malaise.

摘要

近年来,植入式泵的小型化取得进展,且具备通过远程传输进行控制的能力,这使得能够植入可自主向腹腔注射胰岛素的泵。56例糖尿病患者植入了66台泵,每位患者的平均使用期限为21.8个月。至今无患者死亡。植入部件的耐受性良好。发病率仅限于局部事件,在本系列中出现了4例皮肤糜烂,其中2例导致最终取出泵。平均血糖、餐前和餐后血糖以及糖化血红蛋白的剂量均低于植入前的剂量。平均血糖方面显示出统计学上的显著差异。严重低血糖事件(本系列中有4例)和生物性低血糖(血糖<65mg/100ml)的发生频率降低,这是该技术的主要益处。患者的幸福感和生活质量得到显著改善。植入式胰岛素泵可作为传统胰岛素治疗的替代疗法,尤其适用于难以平衡血糖的糖尿病患者,特别是那些频繁出现低血糖不适的患者。

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验