Bogstedt A K, Nord C E, Hammarström L
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.
Eur J Clin Microbiol Infect Dis. 1995 Jan;14(1):61-4. doi: 10.1007/BF02112623.
The aim of this study was to investigate the influence of large doses of orally administered human IgG on the normal gastrointestinal microflora of healthy volunteers since human immunoglobulin has been tried as oral prophylaxis and therapy in gastrointestinal infections. Ten adult healthy volunteers received 10 g of IgG orally, once daily for three consecutive days. Aerobic and anaerobic microorganisms were identified in the saliva and stool specimens, using morphological, biochemical and serological tests and gas-liquid chromatography. Although the immunoglobulin preparation contains antibodies against a variety of microorganisms, there were no significant changes in the numbers of different aerobic and anaerobic microorganisms due to the oral intake of the immunoglobulin. IgG may, therefore, be used against pathogens without disturbing the normal oral and intestinal microflora.
本研究的目的是调查大剂量口服人免疫球蛋白对健康志愿者正常胃肠道微生物群的影响，因为人免疫球蛋白已被尝试用于胃肠道感染的口服预防和治疗。10名成年健康志愿者连续3天每天口服10克免疫球蛋白。通过形态学、生化、血清学检测和气液色谱法对唾液和粪便标本中的需氧和厌氧微生物进行鉴定。尽管免疫球蛋白制剂含有针对多种微生物的抗体，但口服免疫球蛋白后，不同需氧和厌氧微生物的数量没有显著变化。因此，免疫球蛋白可用于对抗病原体，而不会干扰正常的口腔和肠道微生物群。
