人肾小球系膜细胞中的A2腺苷受体。
A2 adenosine receptors in human glomerular mesangial cells.
作者信息
Stefanović V, Vlahović P
机构信息
Institute of Nephrology and Hemodialysis, Faculty of Medicine, Nis, Yugoslavia.
出版信息
Experientia. 1995 Apr 15;51(4):360-2. doi: 10.1007/BF01928895.
A2 adenosine receptors were characterized in human glomerular mesangial cells using [3H]5'-N-ethylcarboxamidoadenosine (NECA) as a tracer. There was a single group of receptor sites with a KD of 184 nM, and a number of sites of 317 fmol/mg of cell protein. Adenosine agonists increased 5'-nucleotidase activity via A2 receptor stimulation. The specific A2 agonist-NECA, at 0.1 and 1 micron, was a potent inhibitor of DNA synthesis.
使用[3H]5'-N-乙基羧基酰胺腺苷（NECA）作为示踪剂，对人肾小球系膜细胞中的A2腺苷受体进行了表征。存在一组KD为184 nM的受体位点，细胞蛋白含量为317 fmol/mg的多个位点。腺苷激动剂通过刺激A2受体增加5'-核苷酸酶活性。特异性A2激动剂NECA，浓度为0.1和1微米时，是DNA合成的有效抑制剂。
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