Olsen A O, Gjøen K, Sauer T, Orstavik I, Naess O, Kierulf K, Sponland G, Magnus P
Department of Epidemiology, National Institute of Public Health, Oslo, Norway.
Int J Cancer. 1995 May 4;61(3):312-5. doi: 10.1002/ijc.2910610306.
The association between certain human papillomaviruses (HPV) and cervical intraepithelial neoplasia (CIN) is well documented, but there is uncertainty about the strength of association and the role of co-factors is unclear. This population-based case-control study in Norwegian women 20-44 years of age included 103 cases with histologically confirmed CIN II-III and 234 age-matched and randomly selected controls. Cytological specimens from the cervix were analyzed using the polymerase chain reaction (PCR). In all, 91% of the cases and 15% of the controls were HPV DNA positive, giving a crude odds ratio (OR) of 67.2 (95% confidence interval: 28.6-157.5). The association between HPV 16 and CIN II-III was even stronger (crude OR = 123.9; 46.7 - 328.5). In logistic regression analysis, additional to HPV, only a high number of sexual partners and a low educational level contributed independently to the risk. The adjusted OR for the association between HPV and CIN II-III was 72.8 (95% CI: 27.6-191.9). The association between HPV and CIN remains very strong even after adjustment for proposed confounding factors. The results therefore support the role of HPV as a causative agent in the development of CIN.
某些人乳头瘤病毒（HPV）与宫颈上皮内瘤变（CIN）之间的关联已有充分记录，但关联强度尚不确定，且协同因素的作用也不明确。这项基于人群的病例对照研究纳入了103例经组织学确诊为CIN II - III级的20 - 44岁挪威女性患者以及234名年龄匹配且随机选取的对照。使用聚合酶链反应（PCR）分析宫颈的细胞学标本。总体而言，91%的病例和15%的对照HPV DNA呈阳性，粗比值比（OR）为67.2（95%置信区间：28.6 - 157.5）。HPV 16与CIN II - III之间的关联更强（粗OR = 123.9；46.7 - 328.5）。在逻辑回归分析中，除HPV外，只有性伴侣数量多和教育水平低独立增加患病风险。HPV与CIN II - III关联的校正OR为72.8（95%CI：27.6 - 191.9）。即使在对潜在混杂因素进行校正后，HPV与CIN之间的关联仍然很强。因此，结果支持HPV在CIN发生发展中作为致病因素的作用。
