[乳腺癌的局部区域复发]

[Locoregional recurrences of breast cancer].

作者信息

Molitor J L, Demuynck B, Louvet C, Varette C, Marpeau L, de Gramont A, Delfau S, Soubrane D, Pigné A, Barrat J

机构信息

Service de Médecine Interne-Oncologie, Hôpital Saint-Antoine, Paris.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 1995;24(1):13-8.

PMID:7730560

Abstract

AIM OF THE STUDY

To determine the characteristics of 51 cases of isolated local regional breast cancer recurrence.

METHODS

Retrospective study from 1980 to 1992, survival calculated according to Kaplan-Meier and log-rank test.

RESULTS

Twenty-five patients had had a conservative treatment of her primary tumour, 26 had been treated by modified radical mastectomy. Local regional recurrence rate was 9%: 44% of recurrences after lumpectomy and 43% of recurrences after mastectomy occurred within 2 years after the initial treatment. Site of local regional recurrence was chest wall only (16 cases), breast only (15 cases) or axillary or supraclavicular node with or without chest wall or breast involvement (20 cases). The actuarial 5-year survival rate after recurrence is 54%. It depends on the time to recurrence (40% if time to recurrence was less than 2 years, 68% if more than 2 years, p < 0.10), on initial node involvement (36% for N+, 71% for N-, p < 0.15) and on the site of recurrence (chest wall: 43%; breast: 48%; regional node: 12%, p < 0.10).

CONCLUSION

Like in the literature, severe recurrences are early recurrences, lymph node recurrences and recurrences following a primary tumour with involved axillary nodes.

摘要

研究目的

确定51例孤立性局部区域乳腺癌复发的特征。

方法

对1980年至1992年进行回顾性研究，采用Kaplan-Meier法计算生存率并进行对数秩检验。

结果

25例患者对其原发性肿瘤进行了保守治疗，26例接受了改良根治性乳房切除术。局部区域复发率为9%：乳房肿瘤切除术后44%的复发以及乳房切除术后43%的复发发生在初始治疗后的2年内。局部区域复发部位仅为胸壁（16例）、仅为乳房（15例）或腋窝或锁骨上淋巴结伴或不伴有胸壁或乳房受累（20例）。复发后的精算5年生存率为54%。它取决于复发时间（如果复发时间小于2年为40%，如果大于2年为68%，p<0.10）、初始淋巴结受累情况（N+为36%，N-为71%，p<0.15）以及复发部位（胸壁：43%；乳房：48%；区域淋巴结：12%，p<0.10）。