Hamasaki T
Department of Obstetrics and Gynecology, Nagasaki University School of Medicine.
Nihon Sanka Fujinka Gakkai Zasshi. 1995 Apr;47(4):385-90.
This study examined the plasma glucose level and immunoreactive insulin (IRI) level in the course of 75g oral glucose tolerance test (OGTT) during pregnancy in 27 obese women (pre-pregnant body mass index (BMI) > = 24kg/m2) and 53 non-obese women (BMI < 24kg/m2). In women with normal glucose tolerance, the fasting IRI level, IRI area under a 3-h curve during 75gOGTT (IRI-AUC) and the net increase in IRI areas above fasting values under a 3-h curve (delta IRI-AUC) in 15 obese women were higher than those in 47 non-obese women (p < 0.01, p < 0.05, p < 0.03), but there was no difference between the two groups in the fasting plasma glucose level, BS-AUC or delta BS-AUC. In women with abnormal glucose tolerance, the fasting IRI level in 12 obese women was higher than that in 6 non-obese women (p < 0.01), but there were no significant differences in the other factors. The fasting IRI level was correlated with the fasting plasma glucose level, BS-AUC, IRI-AUC and BMI (p < 0.002, p < 0.001, p < 0.0001, p < 0.0001). These results show that there is a higher insulin level and lower systemic sensitivity to insulin in obese women than in non-obese women in all groups.
本研究检测了27名肥胖女性（孕前体重指数（BMI）>=24kg/m²）和53名非肥胖女性（BMI<24kg/m²）在孕期进行75g口服葡萄糖耐量试验（OGTT）过程中的血糖水平和免疫反应性胰岛素（IRI）水平。在糖耐量正常的女性中，15名肥胖女性的空腹IRI水平、75g OGTT期间3小时曲线下的IRI面积（IRI-AUC）以及3小时曲线下高于空腹值的IRI面积净增加值（δIRI-AUC）均高于47名非肥胖女性（p<0.01，p<0.05，p<0.03），但两组在空腹血糖水平、血糖曲线下面积（BS-AUC）或δBS-AUC方面无差异。在糖耐量异常的女性中，12名肥胖女性的空腹IRI水平高于6名非肥胖女性（p<0.01），但其他因素无显著差异。空腹IRI水平与空腹血糖水平、BS-AUC、IRI-AUC和BMI相关（p<0.002，p<0.001，p<0.0001，p<0.0001）。这些结果表明，在所有组中，肥胖女性的胰岛素水平高于非肥胖女性，且全身对胰岛素的敏感性低于非肥胖女性。
