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本文引用的文献

1
Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2).假定的第四个跨膜结构域中的亮氨酸143对于氨氯地平抑制上皮钠/氢交换异构体（NHE - 2）至关重要。
Biochem Biophys Res Commun. 1993 Jun 15;193(2):532-9. doi: 10.1006/bbrc.1993.1656.
2
Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C.克隆的上皮钠/氢交换体（NHE3）的功能特性：对氨氯吡咪的抗性及蛋白激酶C的抑制作用
Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9110-4. doi: 10.1073/pnas.90.19.9110.
3
Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family.哺乳动物Na+/H+交换体基因家族上皮亚型的结构/功能研究
J Membr Biol. 1993 Aug;135(2):93-108. doi: 10.1007/BF00231435.
4
CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor.环磷酸腺苷（CAMP）介导的对肾刷状缘膜钠氢交换体的抑制作用需要一种可解离的磷蛋白辅因子。
J Clin Invest. 1993 Oct;92(4):1781-6. doi: 10.1172/JCI116767.
5
Ca(2+)-dependent heat production by rat skeletal muscle in hypertonic media depends on Na(+)-Cl- co-transport stimulation.高渗介质中大鼠骨骼肌的钙依赖产热取决于钠氯共转运刺激。
J Physiol. 1993 Feb;461:689-703. doi: 10.1113/jphysiol.1993.sp019536.
6
Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger.大鼠钠/氢交换体的阿米洛利高亲和力（NHE-1）和低亲和力（NHE-3）亚型的异源表达及功能特性
J Biol Chem. 1993 Aug 5;268(22):16369-77.
7
A point mutation of the Na+/H+ exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis.钠氢交换体基因（NHE1）的点突变以及突变等位基因的扩增会使慢性酸中毒产生氨氯地平抗性。
Proc Natl Acad Sci U S A. 1993 May 15;90(10):4508-12. doi: 10.1073/pnas.90.10.4508.
8
Role of cytoplasmic domain of the Na+/H+ exchanger in hormonal activation.钠离子/氢离子交换体胞质结构域在激素激活中的作用。
J Biol Chem. 1993 Feb 15;268(5):3396-400.
9
Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform.糖皮质激素刺激回肠钠吸收细胞刷状缘的钠/氢交换，并与上皮钠/氢交换异构体NHE-3的信使增加相关。
J Biol Chem. 1993 Jan 5;268(1):206-11.
10
Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers.有证据表明，钠/氢交换体亚型NHE1和NHE3在膜中以稳定的二聚体形式存在，对同型二聚体具有高度特异性。
J Biol Chem. 1994 Jan 28;269(4):2589-96.

哺乳动物钠氢交换体的结构/功能研究——最新进展

Structure/function studies of mammalian Na-H exchangers--an update.

作者信息

Yun C H, Tse C M, Nath S, Levine S L, Donowitz M

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

出版信息

J Physiol. 1995 Jan;482(P):1S-6S. doi: 10.1113/jphysiol.1995.sp020558.

DOI:10.1113/jphysiol.1995.sp020558
PMID:7730970
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1334232/
Abstract

Four mammalian Na+/H+ exchangers have recently been cloned. Despite the structural similarity, these Na+/H+ exchanger isoforms differ in kinetic characteristics and their response to external stimuli. The present review deals with the recent developments in their functional characterization and their short-term regulation.

摘要

最近已克隆出四种哺乳动物的钠/氢交换体。尽管结构相似，但这些钠/氢交换体同工型在动力学特性及其对外界刺激的反应方面存在差异。本综述涉及它们功能特性和短期调节方面的最新进展。