Ito K, Kawaguchi H, Shizume K, Hibi I
Nihon Jinzo Gakkai Shi. 1995 Mar;37(3):186-93.
We treated 90 pediatric patients with chronic renal failure with recombinant growth hormone (r-hGH) for 12 months to improve their growth retardation due to uremia. They were divided into two groups, non-dialyzed and dialyzed children. The dose of r-hGH was 0.5 or 1.0 IU/kg/week in dialyzed children. After 12 months of the treatment using r-hGH, growth velocity was significantly increased in any group of children. Growth velocity was stimulated to about twice as much as before treatment (that were: in non-dialyzed group, 4.2 +/- 2.6cm/year vs. 6.2 +/- 2.0cm/year, P < 0.05, in dialyzed children treated with 0.51U of r-hGH: 2.7 +/- 1.8cm/year vs. 5.2 +/- 2.6cm/year, P < 0.001, and in dialyzed children treated with 1.01U of r-hGH: 3.0 +/- 1.5cm/year vs. 6.3 +/- 2.2cm/year, P < 0.001). No severe side effects was noted and no disturbance of renal function. Our results were consistent with those reported from Europe and USA. We conclude that r-hGH treatment is very effective in improving retarded growth in children with renal disease.
我们用重组生长激素（r-hGH）对90例慢性肾衰竭患儿进行了为期12个月的治疗，以改善其因尿毒症导致的生长发育迟缓。他们被分为两组，未透析儿童和透析儿童。透析儿童使用r-hGH的剂量为0.5或1.0 IU/kg/周。使用r-hGH治疗12个月后，任何一组儿童的生长速度均显著提高。生长速度被刺激到治疗前的约两倍（具体为：未透析组，4.2±2.6厘米/年对6.2±2.0厘米/年，P<0.05；接受0.5 IU r-hGH治疗的透析儿童：2.7±1.8厘米/年对5.2±2.6厘米/年，P<0.001；接受1.0 IU r-hGH治疗的透析儿童：3.0±1.5厘米/年对6.3±2.2厘米/年，P<0.001）。未观察到严重副作用，也未出现肾功能紊乱。我们的结果与欧美报道的结果一致。我们得出结论，r-hGH治疗对改善肾病患儿的生长发育迟缓非常有效。
