Colonna F, Giorgi R, Ciana G, Benettoni A
Centro di Neonatologia, Istituto per l'Infanzia IRCCS, Burlo Garofolo, Trieste.
Minerva Pediatr. 1994 Dec;46(12):553-5.
We describe a premature baby with X pentasomy, having a severe pulmonary hypertension secondary to perinatal asphyxia and hyaline membrane disease which appeared to be refractory to conventional treatments (hyperventilation, tolazoline, prostacyclin). Oxygenation and pulmonary hypertension rapidly improved after starting magnesium sulphate infusion (loading dose: 20 mg/kg e.v. of elementary Mg, followed by continuous infusion of 2-4 mg/kg/hr during 6 days). The therapy was associated with hypermagnesemia (5-7 mg/100 ml) and transitory side effects (hypocalcemia, muscular and bladder paresis, bradycardia without hemodynamic decompensation). We suggest that magnesium therapy might be considered in newborns with severe and persistent pulmonary hypertension.
我们描述了一名患有X五体综合征的早产儿，其因围产期窒息和透明膜病继发严重肺动脉高压，传统治疗方法（过度通气、妥拉唑啉、前列环素）似乎对此无效。在开始输注硫酸镁后（负荷剂量：20mg/kg静脉注射元素镁，随后在6天内持续输注2 - 4mg/kg/小时），氧合和肺动脉高压迅速改善。该治疗伴有高镁血症（5 - 7mg/100ml）和短暂的副作用（低钙血症、肌肉和膀胱麻痹、心动过缓但无血流动力学失代偿）。我们建议，对于患有严重持续性肺动脉高压的新生儿，可考虑使用镁剂治疗。
