Stahl W, Kaneda Y, Tanabe M, Kumar S A
Wadsworth Center for Laboratories and Research, New York State Department of Health, Albany 12201, USA.
Parasitol Res. 1995;81(2):109-13. doi: 10.1007/BF00931614.
Uterine atrophy is a conspicuous finding in Nya:NYLAR female mice chronically infected with Toxoplasma gondii. Administration of 17B-estradiol to infected mice induced a vigorous uterotropic response, i.e., an increase in uterine weight, in endometrial hypertrophy and proliferation, and in the activity of three estrogen-regulated uterine enzymes. These findings rule out a parasite-induced refractoriness of the uterus to estrogen and point to ovarian dysfunction (hypogonadism) as the immediate cause of the uterine atrophy.
子宫萎缩是慢性感染刚地弓形虫的Nya:NYLAR雌性小鼠的一个显著特征。给感染小鼠施用17β-雌二醇会引发强烈的子宫促生长反应，即子宫重量增加、子宫内膜肥大和增殖以及三种雌激素调节的子宫酶活性增加。这些发现排除了寄生虫诱导子宫对雌激素不应答的可能性，并指出卵巢功能障碍（性腺功能减退）是子宫萎缩的直接原因。
