Joshi M G, Crosson A W, Tahan S R
Department of Pathology, Deaconess Hospital, Boston, Massachusetts, USA.
Mod Pathol. 1995 Jan;8(1):1-4.
We report a case of bilateral angiosarcomas developing in breasts after radiation therapy. The angiosarcomas developed 7 years after the first dose and 3 years after the last dose of radiation. In addition, Paget's disease of the nipple was diagnosed in the right breast. c-neu overexpression was noted in the adenocarcinoma but not in the angiosarcoma. Neither tumor was immunoreactive for c-k-ras. The oncogenic expression of the radiation-induced angiosarcoma was different from that of the radiation-resistant adenocarcinoma. The simultaneous occurrence of angiosarcoma and Paget's disease of the nipple has not been reported previously. The importance of recognizing Paget's disease in post-irradiated breasts and complications of breast conservation therapy are stressed.
我们报告一例放疗后双侧乳房发生血管肉瘤的病例。血管肉瘤在首次放疗剂量后7年以及末次放疗剂量后3年出现。此外，右侧乳房诊断为乳头派杰病。腺癌中发现c-neu过表达，但血管肉瘤中未发现。两种肿瘤对c-k-ras均无免疫反应。放疗诱导的血管肉瘤的致癌表达与放疗抵抗的腺癌不同。血管肉瘤与乳头派杰病同时发生此前未见报道。强调了在放疗后乳房中识别派杰病的重要性以及保乳治疗的并发症。
