Pauletzki J, Cicala M, Spengler U, Sauerbruch T, Paumgartner G
Dept. of Medicine II, University of Munich, Germany.
Scand J Gastroenterol. 1995 Feb;30(2):128-32. doi: 10.3109/00365529509093250.
Impaired gallbladder emptying is a pathogenetic factor in gallstone formation. To test whether gallbladder motility can be improved by high-dose cholecystokinin (CCK), gallbladder emptying was measured sonographically in 21 patients with cholesterol gallstone disease and 6 healthy controls.
The effects of CCK infusions of 0.06 IDU/kg.min (group A, n = 11) and 0.12 IDU/kg.min (group B, n = 10) were compared with the response to a standard CCK infusion (0.02 IDU/kg.min). Controls received CCK at all infusion rates.
The ejection fraction was smaller after CCK infusion of 0.06 IDU/kg.min than after the standard stimulus (group A, 52 +/- 10 versus 64 +/- 10%, p < 0.05; controls, 66 +/- 10 versus 91 +/- 3%, p < 0.05). After infusion of 0.12 IDU/kg.min CCK ejection fractions decreased even more (group B, 44 +/- 16 versus 65 +/- 12%, p < 0.05; controls, 54 +/- 12 versus 91 +/- 3%, p < 0.05). High-dose CCK infusions shortened the ejection period markedly, whereas the ejection rate remained unaltered.
High-dose CCK does not improve gallbladder motility but blocks the ejection process early, leading to reduced gallbladder emptying in gallstone patients and healthy subjects.
胆囊排空功能受损是胆结石形成的一个致病因素。为了测试大剂量胆囊收缩素（CCK）是否能改善胆囊运动功能，对21例胆固醇结石病患者和6名健康对照者进行了超声检查以测量胆囊排空情况。
将0.06 IDU/kg.min（A组，n = 11）和0.12 IDU/kg.min（B组，n = 10）的CCK输注效果与标准CCK输注（0.02 IDU/kg.min）的反应进行比较。对照组在所有输注速率下均接受CCK。
输注0.06 IDU/kg.min的CCK后，射血分数低于标准刺激后（A组，52±10%对64±10%，p<0.05；对照组，66±10%对91±3%，p<0.05）。输注0.12 IDU/kg.min的CCK后，射血分数下降得更多（B组，44±16%对65±12%，p<0.05；对照组，54±12%对91±3%，p<0.05）。大剂量CCK输注显著缩短了射血期，而射血速率保持不变。
大剂量CCK不能改善胆囊运动功能，反而早期阻断射血过程，导致胆结石患者和健康受试者的胆囊排空减少。
