Brändle M, Vernazza P L, Oesterle M, Galeazzi R L
Medizinische Klinik A, Kantonsspital St. Gallen.
Schweiz Med Wochenschr. 1995 Apr 8;125(14):684-7.
Endocrine disorders in the course of HIV infection are often a result of opportunistic infections of endocrine organs. We describe the case of a 30-year-old HIV positive man in whom diabetes insipidus developed initially with no abnormal findings in cranial magnetic resonance imaging. 2 months later the patient presented with symptoms of panhypopituitarism. At this time, neuroradiologic examination was consistent with cerebral toxoplasmosis. Symptoms and neuroradiologic findings improved after treatment for cerebral toxoplasmosis. Toxoplasmosis is the most frequent opportunistic infection of the brain in patients with AIDS. In HIV positive patients with malfunction of the hypothalamic-hypophyseal system cerebral toxoplasmosis must be considered in differential diagnosis. Treatment of this disorder may alleviate symptoms and signs of endocrine malfunction.
HIV感染过程中的内分泌紊乱往往是内分泌器官机会性感染的结果。我们描述了一名30岁的HIV阳性男性病例，该患者最初出现尿崩症，头颅磁共振成像未发现异常。2个月后，患者出现全垂体功能减退症状。此时，神经放射学检查结果与脑弓形虫病相符。脑弓形虫病治疗后，症状和神经放射学表现有所改善。弓形虫病是艾滋病患者最常见的脑部机会性感染。对于下丘脑 - 垂体系统功能障碍的HIV阳性患者，鉴别诊断时必须考虑脑弓形虫病。这种疾病的治疗可能会缓解内分泌功能障碍的症状和体征。
