[Vesicoureteropelvic reflux in pregnant animals and its role in the pathogenesis of acute gestational pyelonephritis (experimental research)].

The experiments on naturally pregnant rats have demonstrated that pregnancy contributes to much more frequent occurrence of vesicoureteropelvic reflux (VUPR) which, in its turn, is essential for pathogenesis of acute gestational pyelonephritis (AGP). Dynamic obstruction of the urine flow as a result of reduced function of leiomyocytes of urinary tract muscles, decreased urothelial glycocalyx and consequent adhesion of pathogenic agents comprise parts of this pathogenesis. The conclusion is made that VUPR pregnant females are at risk to develop AGP and should be placed by the urologist on ultrasonic monitoring lasting all pregnancy and postpartum periods.