Shabad A L, Khodyreva L A, Kudriavtsev Iu V, Kirpatovskiĭ V I
Urol Nefrol (Mosk). 1995 Jan-Feb(1):13-6.
The experiments on naturally pregnant rats have demonstrated that pregnancy contributes to much more frequent occurrence of vesicoureteropelvic reflux (VUPR) which, in its turn, is essential for pathogenesis of acute gestational pyelonephritis (AGP). Dynamic obstruction of the urine flow as a result of reduced function of leiomyocytes of urinary tract muscles, decreased urothelial glycocalyx and consequent adhesion of pathogenic agents comprise parts of this pathogenesis. The conclusion is made that VUPR pregnant females are at risk to develop AGP and should be placed by the urologist on ultrasonic monitoring lasting all pregnancy and postpartum periods.
对自然受孕大鼠的实验表明，怀孕会导致膀胱输尿管肾盂反流（VUPR）更频繁地发生，而这反过来又是急性妊娠期肾盂肾炎（AGP）发病机制的关键因素。由于尿路肌肉平滑肌功能减退、尿路上皮糖萼减少以及病原体随之附着而导致的尿流动态梗阻是这一发病机制的组成部分。得出的结论是，患有VUPR的怀孕女性有患AGP的风险，泌尿科医生应在整个孕期和产后对其进行超声监测。
