Gaudet J P, Hashimoto L, Sadovnick A D, Ebers G C
Multiple Sclerosis Clinic, University Hospital, London, Ontario, Canada.
Acta Neurol Scand. 1995 Jan;91(1):19-21. doi: 10.1111/j.1600-0404.1995.tb05837.x.
Birth order position was examined in 164 cases with sporadic multiple sclerosis (MS), i.e. no other family members with MS, and spousal controls, matched for sibship size, socioeconomic status and opposite sex. The results did not find an association between birth order position and the subsequent development of MS and thus do not support the concept of an infectious cause for MS where "early exposure" is protective and exposure to the infection is a single event of short duration.
对164例散发性多发性硬化症（MS）患者进行了出生顺序研究，即没有其他家庭成员患有MS，并与配偶进行对照，后者在同胞数量、社会经济地位和性别方面相匹配。结果未发现出生顺序与随后发生MS之间存在关联，因此不支持MS的感染病因概念，即“早期接触”具有保护作用且感染接触是一次短期单一事件。
