von Ardenne M, Krüger W
Arch Geschwulstforsch. 1975;45(6):572-80.
With Jerne's plaque technique it was possible to verify that a new compound, termed BA 1, features pronounced immuno-stimulating properties. After single-shot i. v. application of 150 mg/kg body weight this immuno-stimulating action can be demonstrated by way of a significant increase of the plaque numbers compared to untreated controls in healthy mice and, in a somewhat diminished form, also in mice bearing Ehrlich ascites carcinoma. Furthermore, it has been shown that the plaque test proves to be suitable as parameter to describe the defense status in tumor-bearing animals as, in the case of Ehrlich carcinomas, there is a distinct negative correlation between plaque numbers and age or mass of the tumor.
利用耶尔恩的空斑技术能够证实，一种名为BA 1的新化合物具有显著的免疫刺激特性。在以150毫克/千克体重单次静脉注射后，与未处理的健康小鼠对照组相比，空斑数量显著增加，从而证明了这种免疫刺激作用，并且在患有艾氏腹水癌的小鼠中，这种作用虽有所减弱但仍可显现。此外，还表明空斑试验被证明适合作为描述荷瘤动物防御状态的参数，因为在艾氏癌的情况下，空斑数量与肿瘤的年龄或大小之间存在明显的负相关。
