Harris R B, Martin R J, Bruch R C
Department of Foods and Nutrition, University of Georgia, Athens 30602 USA.
Am J Physiol. 1995 Apr;268(4 Pt 2):R874-83. doi: 10.1152/ajpregu.1995.268.4.R874.
When one member of a parabiosed pair of rats is overfed, its ad libitum-fed partner loses body fat in the absence of a statistically significant decrease in food intake. Three experiments investigated the relationships between food intake, metabolism, and body composition in this model. In vivo measurement of lipogenesis confirmed that loss of fat is associated with decreased fat deposition. When partners of overfed rats were compared with food-restricted single rats, proportional changes in body composition and metabolism were similar for the two treatments, although there was no significant change in the food intake of parabiotic rats, whereas restricted rats received only 60% of the intake of their controls. The final experiment demonstrated that changes in body composition of partners of overfed rats were independent of dietary composition. These results suggest that, when a rat is made obese by overfeeding, a circulatory factor is released that inhibits fat deposition and disrupts regulatory mechanisms that normally stimulate food intake during a period of negative energy balance.
当联体共生的一对大鼠中的一只被过度喂食时，其自由采食的伙伴在食物摄入量没有统计学显著下降的情况下会减少体脂。三项实验研究了该模型中食物摄入、新陈代谢和身体组成之间的关系。体内脂肪生成测量证实，脂肪减少与脂肪沉积减少有关。将过度喂食大鼠的伙伴与食物受限的单独大鼠进行比较时，两种处理的身体组成和新陈代谢的比例变化相似，尽管联体共生大鼠的食物摄入量没有显著变化，而受限大鼠的摄入量仅为其对照组的60%。最后一项实验表明，过度喂食大鼠的伙伴的身体组成变化与饮食组成无关。这些结果表明，当一只大鼠因过度喂食而肥胖时，会释放一种循环因子，该因子会抑制脂肪沉积，并破坏在负能量平衡期间通常刺激食物摄入的调节机制。
