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[用于实验性动脉粥样硬化免疫形态学研究的抗主动脉抗原免疫血清的分离]

[Isolation of immune serums against antigens of the aorta for immunomorphological study of experimental atherosclerosis].

作者信息

Ivanovskiĭ Iu V, Nagornev V A, Zubzhitskiĭ Iu N

出版信息

Arkh Patol. 1975;37(10):72-7.

PMID:773346
Abstract

A possibility is shown of obtaining sufficiently pure antigens (collagen, elastin, structural grycoproteids), with the help of a preparative chemical method, from the wall of aortas of rabbits, both healthy and "diseased", i.e. with atherosclerosis. Immunomorphological analysis showed that the immune sera obtained against antigens indicated above reacted only with structures of the affected vessels, no interaction with the wall of normal aortas being noted.

摘要

结果表明,有可能借助制备性化学方法,从健康和“患病”(即患有动脉粥样硬化)的兔主动脉壁中获取足够纯净的抗原(胶原蛋白、弹性蛋白、结构糖蛋白)。免疫形态学分析显示,针对上述抗原获得的免疫血清仅与病变血管的结构发生反应,未观察到与正常主动脉壁有相互作用。

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