• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.

作者信息

Karinch A M, Floros J

机构信息

Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey 17033, USA.

出版信息

Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):327-30. doi: 10.1042/bj3070327.

DOI:10.1042/bj3070327
PMID:7733864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1136651/
Abstract

Transcripts of human SP-A genes, SP-A1 and SP-A2, undergo alternative splicing of 5' untranslated-region exons. We reverse-transcribed and amplified free cytoplasmic and polysome-bound RNA and showed that (a) all splice variants of both genes are translated in vivo, (b) the relative translatability of splice variants can differ among individuals, and (c) the relative levels of different SP-A splice variants differ among individuals.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/ba9b48322ab9/biochemj00065-0026-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/84a52bfab8d3/biochemj00065-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/54b84e661ab6/biochemj00065-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/ba9b48322ab9/biochemj00065-0026-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/84a52bfab8d3/biochemj00065-0025-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/54b84e661ab6/biochemj00065-0026-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/690d/1136651/ba9b48322ab9/biochemj00065-0026-b.jpg

相似文献

1
Translation in vivo of 5' untranslated-region splice variants of human surfactant protein-A.
Biochem J. 1995 Apr 15;307 ( Pt 2)(Pt 2):327-30. doi: 10.1042/bj3070327.
2
5' splicing and allelic variants of the human pulmonary surfactant protein A genes.
Am J Respir Cell Mol Biol. 1995 Jan;12(1):77-88. doi: 10.1165/ajrcmb.12.1.7811473.
3
Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humans.基因型对成年人体内表面活性物质蛋白A mRNA水平及SP - A2剪接变体的影响。
Biochem J. 1997 Jan 1;321 ( Pt 1)(Pt 1):39-47. doi: 10.1042/bj3210039.
4
Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes.人SP-A1和SP-A2基因的mRNA转录本特征及基因组织
Am J Physiol. 1994 Apr;266(4 Pt 1):L354-66. doi: 10.1152/ajplung.1994.266.4.L354.
5
Characterization of two baboon surfactant protein A genes.
Am J Physiol. 1996 Oct;271(4 Pt 1):L617-30. doi: 10.1152/ajplung.1996.271.4.L617.
6
Surfactant protein A2 gene expression by human airway submucosal gland cells.人呼吸道黏膜下腺细胞的表面活性物质蛋白A2基因表达
Am J Respir Cell Mol Biol. 1998 Aug;19(2):202-9. doi: 10.1165/ajrcmb.19.2.3239.
7
Rabbit surfactant protein C: cDNA cloning and regulation of alternatively spliced surfactant protein C mRNAs.
Am J Physiol. 1992 Dec;263(6 Pt 1):L634-44. doi: 10.1152/ajplung.1992.263.6.L634.
8
cDNA sequence and alternative mRNA splicing of surfactant-associated protein C (SP-C) in rabbit lung.兔肺表面活性物质相关蛋白C（SP-C）的cDNA序列及可变mRNA剪接
Biochim Biophys Acta. 1992 Jul 29;1127(2):199-207. doi: 10.1016/0005-2760(92)90278-4.
9
Human surfactant proteins A1 and A2 are differentially regulated during development and by soluble factors.人表面活性蛋白A1和A2在发育过程中以及受可溶性因子影响时受到不同的调节。
Am J Physiol. 1998 Oct;275(4):L653-69. doi: 10.1152/ajplung.1998.275.4.L653.
10
Genetics of the hydrophilic surfactant proteins A and D.
Biochim Biophys Acta. 1998 Nov 19;1408(2-3):312-22. doi: 10.1016/s0925-4439(98)00077-5.

引用本文的文献

1
Differential Regulation of Human Surfactant Protein A Genes, SFTPA1 and SFTPA2, and Their Corresponding Variants.人表面活性蛋白 A 基因（SFTPA1 和 SFTPA2）及其变异体的差异调控。
Front Immunol. 2021 Nov 30;12:766719. doi: 10.3389/fimmu.2021.766719. eCollection 2021.
2
Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.人表面活性蛋白 A1 和 A2 变体在肺泡微环境、表面活性物质结构、肺泡巨噬细胞调节和功能以及各种条件下动物和人类的生存方面具有不同的影响。
Front Immunol. 2021 Aug 17;12:681639. doi: 10.3389/fimmu.2021.681639. eCollection 2021.
3

本文引用的文献

1
DETERMINATION OF THE CODING RATIO BASED ON MOLECULAR WEIGHT OF MESSENGER RIBONUCLEIC ACID ASSOCIATED WITH ERGOSOMES OF DIFFERENT AGGREGATE SIZE.基于与不同聚集体大小的麦角体相关的信使核糖核酸分子量确定编码率
Nature. 1964 Jan 18;201:264-70. doi: 10.1038/201264a0.
2
Immunogold localization of SP-A in lungs of infants dying from respiratory distress syndrome.死于呼吸窘迫综合征的婴儿肺部表面活性蛋白A的免疫金定位
Am J Pathol. 1993 May;142(5):1631-40.
3
Surfactant and the adult respiratory distress syndrome.表面活性剂与成人呼吸窘迫综合征
The Importance of Redox Status in the Frame of Lifestyle Approaches and the Genetics of the Lung Innate Immune Molecules, SP-A1 and SP-A2, on Differential Outcomes of COVID-19 Infection.
氧化还原状态在生活方式干预框架中的重要性以及肺固有免疫分子SP-A1和SP-A2的遗传学对COVID-19感染不同结局的影响
Antioxidants (Basel). 2020 Aug 25;9(9):784. doi: 10.3390/antiox9090784.
4
Structure, genetics and function of the pulmonary associated surfactant proteins A and D: The extra-pulmonary role of these C type lectins.肺相关表面活性蛋白A和D的结构、遗传学与功能：这些C型凝集素在肺外的作用
Ann Anat. 2017 May;211:184-201. doi: 10.1016/j.aanat.2017.03.002. Epub 2017 Mar 27.
5
14-3-3 isoforms bind directly exon B of the 5'-UTR of human surfactant protein A2 mRNA.14-3-3 同工型直接结合人表面活性蛋白A2 mRNA 5'-非翻译区的外显子B。
Am J Physiol Lung Cell Mol Physiol. 2015 Jul 15;309(2):L147-57. doi: 10.1152/ajplung.00088.2015. Epub 2015 May 22.
6
Regulation of translation by upstream translation initiation codons of surfactant protein A1 splice variants.翻译起始密码子上游对肺表面活性蛋白 A1 剪接变体翻译的调控。
Am J Physiol Lung Cell Mol Physiol. 2015 Jan 1;308(1):L58-75. doi: 10.1152/ajplung.00058.2014. Epub 2014 Oct 17.
7
Exon B of human surfactant protein A2 mRNA, alone or within its surrounding sequences, interacts with 14-3-3; role of cis-elements and secondary structure.人表面活性蛋白 A2 mRNA 的外显子 B 单独或与其周围序列相互作用 14-3-3；顺式元件和二级结构的作用。
Am J Physiol Lung Cell Mol Physiol. 2013 Jun 1;304(11):L722-35. doi: 10.1152/ajplung.00324.2012. Epub 2013 Mar 22.
8
Genetic complexity of the human surfactant-associated proteins SP-A1 and SP-A2.人类表面活性剂相关蛋白 SP-A1 和 SP-A2 的遗传复杂性。
Gene. 2013 Dec 1;531(2):126-32. doi: 10.1016/j.gene.2012.09.111. Epub 2012 Oct 12.
9
Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury.人类 SP-A 和 SP-D 的遗传变异与急性和慢性肺损伤的关联。
Front Biosci (Landmark Ed). 2012 Jan 1;17(2):407-29. doi: 10.2741/3935.
10
The untranslated exon B of human surfactant protein A2 mRNAs is an enhancer for transcription and translation.人表面活性蛋白 A2 mRNA 的未翻译外显子 B 是转录和翻译的增强子。
Am J Physiol Lung Cell Mol Physiol. 2011 Nov;301(5):L795-803. doi: 10.1152/ajplung.00439.2010. Epub 2011 Aug 12.
Am Rev Respir Dis. 1993 Jan;147(1):218-33. doi: 10.1164/ajrccm/147.1.218.
4
Structure/function relationships in the collectins (mammalian lectins containing collagen-like regions).凝集素（含有胶原样区域的哺乳动物凝集素）中的结构/功能关系。
Biochem Soc Trans. 1993 May;21(2):464-8. doi: 10.1042/bst0210464.
5
Human SP-A: genotype and single-strand conformation polymorphism analysis.
Am J Physiol. 1994 May;266(5 Pt 1):L519-27. doi: 10.1152/ajplung.1994.266.5.L519.
6
Human SP-A1 and SP-A2 genes are differentially regulated during development and by cAMP and glucocorticoids.人类SP - A1和SP - A2基因在发育过程中以及受环磷酸腺苷（cAMP）和糖皮质激素的影响下受到不同的调控。
Am J Physiol. 1994 Apr;266(4 Pt 1):L367-74. doi: 10.1152/ajplung.1994.266.4.L367.
7
Characterization of mRNA transcripts and organization of human SP-A1 and SP-A2 genes.人SP-A1和SP-A2基因的mRNA转录本特征及基因组织
Am J Physiol. 1994 Apr;266(4 Pt 1):L354-66. doi: 10.1152/ajplung.1994.266.4.L354.
8
Regulation of eukaryotic initiation factor-2 expression during sepsis.脓毒症期间真核生物起始因子-2表达的调控
Am J Physiol. 1994 Feb;266(2 Pt 1):E193-201. doi: 10.1152/ajpendo.1994.266.2.E193.
9
Surfactant protein A and saturated phosphatidylcholine in respiratory distress syndrome.呼吸窘迫综合征中的表面活性物质蛋白A和饱和磷脂酰胆碱
Am J Respir Crit Care Med. 1994 Dec;150(6 Pt 1):1672-7. doi: 10.1164/ajrccm.150.6.7952631.
10
Human SP-A: then and now.
Am J Physiol. 1995 Feb;268(2 Pt 1):L162-5. doi: 10.1152/ajplung.1995.268.2.L162.