Thorin B, Gache G, Dubois T, Grataroli R, Domingo N, Russo-Marie F, Lafont H
INSERM, Unité 130, 18, Marseille, France.
Biochem Biophys Res Commun. 1995 Apr 26;209(3):1039-45. doi: 10.1006/bbrc.1995.1602.
A calcium-binding protein of 68 kDa was isolated from human bile that precipitates upon addition of 5 mM CaCl2. This protein was recognized by an immunoaffinity purified anti-annexin VI antibody and it had a similar aminoacid composition as annexin VI. Phospholipase A2 activity was inhibited in vitro in a dose-dependent manner as reported for annexin VI. It is the first time that an annexin secretion is demonstrated in bile.
