Misao R, Hori M, Ichigo S, Fujimoto J, Tamaya T
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Reprod Nutr Dev. 1995;35(2):155-65. doi: 10.1051/rnd:19950204.
Recently, much evidence has indicated that sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) play a role in the intracellular action of sex steroids in target cells. In the present work, expression of SHBG mRNA and CBG mRNA was demonstrated in tissues of human normal endometrium and pelvic endometriosis, using the reverse transcription-polymerase chain reaction (RT-PCR). SHBG mRNA levels were higher in pelvic endometriosis than in normal endometrium (P < 0.02), while CBG mRNA levels were lower than in normal endometrium (P < 0.05). The SHBG mRNA/CBG mRNA ratio was significantly higher in pelvic endometriosis than in normal endometrium (P < 0.01). These findings suggest that overexpression of intercellular SHBG in endometriotic tissues results in the formation of the estrogen-predominant milieu, since SHBG-bound estrogen is considered to be protected from the metabolism in liver and available in endometrial cells, thereby assisting the development of the pelvic endometriosis.
最近，大量证据表明性激素结合球蛋白（SHBG）和皮质类固醇结合球蛋白（CBG）在靶细胞中性类固醇的细胞内作用中发挥作用。在本研究中，采用逆转录聚合酶链反应（RT-PCR）在人正常子宫内膜和盆腔子宫内膜异位症组织中检测到SHBG mRNA和CBG mRNA的表达。盆腔子宫内膜异位症组织中SHBG mRNA水平高于正常子宫内膜（P < 0.02），而CBG mRNA水平低于正常子宫内膜（P < 0.05）。盆腔子宫内膜异位症组织中SHBG mRNA/CBG mRNA比值显著高于正常子宫内膜（P < 0.01）。这些发现表明，子宫内膜异位症组织中细胞间SHBG的过度表达导致了以雌激素为主的微环境的形成，因为与SHBG结合的雌激素被认为可免受肝脏代谢影响并存在于子宫内膜细胞中，从而促进盆腔子宫内膜异位症的发展。
