Schäcke H, Rinkevich B, Gamulin V, Müller I M, Müller W E
Institut für Physiologische Chemie, Universität, Mainz, Germany.
J Mol Recognit. 1994 Dec;7(4):273-6. doi: 10.1002/jmr.300070406.
We have isolated and characterized two cDNAs from the marine sponge Geodia cydonium coding for a new member of a receptor tyrosine kinase of class II. The deduced amino acid sequence shows two characteristic domains: (i) the tyrosine kinase domain; and (ii) an immunoglobulin-like domain. The latter part shows high homology to the vertebrate C2 type immunoglobulin domain. This result demonstrates that immunoglobulin domains are not recent achievements of higher animals but exist also in those animals which have diverged from other organisms about 800 million years ago.
我们从海洋海绵地穴海绵（Geodia cydonium）中分离并鉴定了两个cDNA，它们编码II类受体酪氨酸激酶的一个新成员。推导的氨基酸序列显示出两个特征结构域：（i）酪氨酸激酶结构域；（ii）免疫球蛋白样结构域。后一部分与脊椎动物的C2型免疫球蛋白结构域具有高度同源性。这一结果表明，免疫球蛋白结构域并非高等动物近期才有的特征，而是在约8亿年前就已与其他生物分化的动物中也存在。
