自身免疫性血小板减少性紫癜（ATP）患者脾切除术后自然杀伤细胞持续淋巴细胞增多。
Persistent lymphocytosis of natural killer cells in autoimmune thrombocytopenic purpura (ATP) patients after splenectomy.
作者信息
Garcia-Suarez J, Prieto A, Reyes E, Arribalzaga K, Perez-Machado M A, Lopez-Rubio M, Manzano L, Alvarez-Mon M
机构信息
Departamento de Medicina, Hospital Universitario Principe de Asturias, Universidad de Alcala de Henares, Madrid, Spain.
出版信息
Br J Haematol. 1995 Mar;89(3):653-5. doi: 10.1111/j.1365-2141.1995.tb08382.x.
We report three patients with primary autoimmune thrombocytopenic purpura (ATP) who developed an absolute lymphocytosis (lymphocyte count > 5 x 10(9)/l) after splenectomy and with a lymphocyte count between 5.4 and 8.9 x 10(9)/l. An immunophenotype study showed that the peripheral blood lymphocytosis was a persistent NK cell expansion (CD2+, CD56+, CD3-), and was characterized by a typical large granular lymphocytes (LGL) morphology. Two of these three ATP patients were refractory to splenectomy.
我们报告了3例原发性自身免疫性血小板减少性紫癜（ATP）患者，他们在脾切除术后出现了绝对淋巴细胞增多（淋巴细胞计数>5×10⁹/L），淋巴细胞计数在5.4至8.9×10⁹/L之间。免疫表型研究表明，外周血淋巴细胞增多是持续性自然杀伤（NK）细胞扩增（CD2⁺、CD56⁺、CD3⁻），其特征为典型的大颗粒淋巴细胞（LGL）形态。这3例ATP患者中有2例对脾切除术无效。
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