自然杀伤细胞在1型糖尿病和免疫治疗中不断扩大的作用
The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy.
作者信息
Fraker Chris, Bayer Allison L
机构信息
Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
出版信息
Curr Diab Rep. 2016 Nov;16(11):109. doi: 10.1007/s11892-016-0806-7.
Treatments for autoimmune diseases including type 1 diabetes (T1D) are aimed at resetting the immune system, especially its adaptive arm. The innate immune system is often ignored in the design of novel immune-based therapies. There is increasing evidence for multiple natural killer (NK) subpopulations, but their role is poorly understood in autoimmunity and likely is contributing to the controversial role reported for NKs. In this review, we will summarize NK subsets and their roles in tolerance, autoimmune diabetes, and immunotherapy.
包括1型糖尿病（T1D）在内的自身免疫性疾病的治疗旨在重置免疫系统，尤其是其适应性分支。在新型免疫疗法的设计中，先天性免疫系统常常被忽视。越来越多的证据表明存在多种自然杀伤（NK）亚群，但它们在自身免疫中的作用却鲜为人知，而且可能导致了有关NK细胞的争议性作用的报道。在这篇综述中，我们将总结NK亚群及其在耐受性、自身免疫性糖尿病和免疫治疗中的作用。
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