Petrakis I, Carroll K, Gordon L, Cushing G, Rounsaville B
Department of Psychiatry, Yale University, New Haven, CT, USA.
J Addict Dis. 1994;13(3):25-32. doi: 10.1300/j069v13n03_03.
Twenty-two methadone maintained opioid addicts with either depression or persistent cocaine use received open label fluoxetine in addition to their methadone. Fluoxetine significantly decreased depressive symptoms from pre-treatment to endpoint in subjects with depression, while its effect on substance use was inconclusive.