Chukwuma C
Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland.
J Diabetes Complications. 1995 Jan-Mar;9(1):55-67. doi: 10.1016/1056-8727(94)00004-8.
The magnitude of type II diabetic nephropathy dilemma is observable in the growing number of diabetic patients with end-stage renal lesion receiving various modalities of treatment. Progressive glomerulopathy associated with proteinuria and hypertension is strongly causative of renal failure and mortality in diabetic patients. Besides hypertension, diabetes exceeds all other glomerulopathies in causing end-stage renal failure. Alterations in glomerular structure and function observed in diabetic patients are implicated in the development and progression of renal derangement. Diabetic glomerulosclerosis, an aggregate of structural and functional perturbations of the kidney, is indicated by alterations in the accumulation of extracellular matrix components, The pathology, epidemiology, risk factors, and other dependent variables may throw some light in the pathogenetic mechanisms and the prevention, treatment, and management modalities of type II diabetic nephropathy.
II型糖尿病肾病困境的严重程度在越来越多患有终末期肾脏病变并接受各种治疗方式的糖尿病患者中可见一斑。与蛋白尿和高血压相关的进行性肾小球病是糖尿病患者肾衰竭和死亡的强烈病因。除高血压外，糖尿病在导致终末期肾衰竭方面超过所有其他肾小球病。糖尿病患者中观察到的肾小球结构和功能改变与肾脏紊乱的发生和发展有关。糖尿病肾小球硬化是肾脏结构和功能紊乱的总和，表现为细胞外基质成分积累的改变。病理学、流行病学、危险因素和其他相关变量可能有助于揭示II型糖尿病肾病的发病机制以及预防、治疗和管理方式。
