胍乙啶与氧烯洛尔联合治疗高血压的试验
Trial of combination of guanethidine and oxprenolol in hypertension.
作者信息
Pearson R M, Bending M R, Bulpitt C J, George C F, Hole D R, Williams F M, Breckenridge A M
出版信息
Br Med J. 1976 Apr 17;1(6015):933-6. doi: 10.1136/bmj.1.6015.933.
Abstract
Thirteen hypertensive patients entered a double-blind crossover trial of guanethidine and oxprenolol in combination. In nine patients who completed the trial there was an additive effect on blood pressure, but the combination had a smaller effect on heart rate than was expected from the individual effects, and side effects were not increased. During treatment with oxprenolol the plasma potassium concentration rose from 3.6 mmol (mEq)/1 to 3.9 mmol (mEq)/1. No correlation was found between the plasma oxprenolol concentration and changes in blood pressure or response to injected isoprenaline, but measurements of plasma oxprenolol concentrations were of value in determining compliance with the protocol.
摘要
13名高血压患者参与了胍乙啶和氧烯洛尔联合用药的双盲交叉试验。在完成试验的9名患者中，联合用药对血压有相加作用，但联合用药对心率的影响小于根据单药作用预期的效果，且副作用并未增加。在使用氧烯洛尔治疗期间，血浆钾浓度从3.6毫摩尔/升（毫当量/升）升至3.9毫摩尔/升（毫当量/升）。未发现血浆氧烯洛尔浓度与血压变化或对注射异丙肾上腺素的反应之间存在相关性，但血浆氧烯洛尔浓度的测定对于确定是否遵守方案具有价值。
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