Rossi R, Danzebrink S, Linnenbürger K, Hillebrand D, Grüneberg M, Sablitzky V, Deufel T, Ullrich K, Harms E
University Children's Hospital, Münster, Germany.
Acta Paediatr. 1994 Dec;83(12):1282-6. doi: 10.1111/j.1651-2227.1994.tb13017.x.
Reference values for tubular transport of sodium, phosphate, glucose and amino acids are generally based on inulin or creatinine short-term clearances, which are difficult to obtain in children. Hence, quantitative assessment of tubular transport capacities is rarely performed. For a simplified procedure, reference values for fractional sodium excretion, phosphate reabsorption related to glomerular filtration rate, percent glucose and percent amino acid reabsorption were established in 62 children from spot urine and simultaneously obtained blood samples. Sodium excretion, and glucose and amino acid reabsorption were significantly lower in infants than children, whereas phosphate reabsorption decreased during the first year of life. Results using the proposed protocol and those obtained from timed urine specimens correlated well; the phenomenon of renal adaptation during childhood could equally well be demonstrated. Renal tubular dysfunction can be diagnosed without timed urine specimens.
钠、磷酸盐、葡萄糖和氨基酸的肾小管转运参考值通常基于菊粉或肌酐短期清除率，而这在儿童中很难获得。因此，很少进行肾小管转运能力的定量评估。为了简化程序，从即时尿样和同时采集的血样中，为62名儿童建立了分数钠排泄、与肾小球滤过率相关的磷酸盐重吸收、葡萄糖重吸收百分比和氨基酸重吸收百分比的参考值。婴儿的钠排泄、葡萄糖和氨基酸重吸收明显低于儿童，而磷酸盐重吸收在生命的第一年有所下降。使用所提议方案得到的结果与定时尿样得到的结果相关性良好；儿童期肾脏适应现象也能同样得到证实。无需定时尿样即可诊断肾小管功能障碍。
