中-2,3-二巯基丁二酸或2,3-二巯基丙烷-1-磺酸盐对大鼠慢性砷中毒的治疗潜力

Therapeutic potential of meso 2,3-dimercaptosuccinic acid or 2,3-dimercaptopropane 1-sulfonate in chronic arsenic intoxication in rats.

作者信息

Flora S J, Dube S N, Arora U, Kannan G M, Shukla M K, Malhotra P R

机构信息

Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Gwalior, India.

出版信息

Biometals. 1995 Apr;8(2):111-6. doi: 10.1007/BF00142009.

DOI:10.1007/BF00142009

PMID:7734923

Abstract

The therapeutic efficacy of two thiol chelators, meso 2,3-dimercaptosuccinic acid (DMSA) or 2,3-dimercaptopropane sulfonate (DMPS) in treating chronic arsenic intoxication was investigated in male rats. Both the chelators were effective in promoting urinary arsenic excretion and restoring arsenic induced inhibition of blood delta-aminolevulinic acid dehydratase activity and hepatic glutathione level. Elevation of urinary delta-aminolevulinic acid excretion and arsenic concentration in blood, liver and kidneys were reduced significantly by both the chelators. Histopathological lesions induced by arsenic were also effectively reduced by the above chelators. DMSA being more effective than DMPS. The results suggest DMSA and DMPS to be effective antidotes for treating chronic arsenic toxicity in experimental animals.

摘要

在雄性大鼠中研究了两种巯基螯合剂，即内消旋2,3-二巯基丁二酸（DMSA）或2,3-二巯基丙烷磺酸钠（DMPS）治疗慢性砷中毒的疗效。两种螯合剂均能有效促进尿砷排泄，并恢复砷诱导的血液δ-氨基乙酰丙酸脱水酶活性抑制和肝脏谷胱甘肽水平。两种螯合剂均能显著降低尿δ-氨基乙酰丙酸排泄量以及血液、肝脏和肾脏中砷的浓度。上述螯合剂也有效减轻了砷诱导的组织病理学损伤。DMSA比DMPS更有效。结果表明，DMSA和DMPS是治疗实验动物慢性砷中毒的有效解毒剂。