Iontophoretic delivery of oligonucleotide derivatives into mouse tumor.
作者信息
Vlassov V V, Nechaeva M V, Karamyshev V N, Yakubov L A
机构信息
Institute of Bioorganic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk.
出版信息
Antisense Res Dev. 1994 Winter;4(4):291-3. doi: 10.1089/ard.1994.4.291.
PMID:7734944
Abstract
Oligodeoxyribonucleotides (22-mers) were delivered through the skin of C3H mice in the region of a mammary gland tumor by means of iontophoresis. It was shown that the oligonucleotides enter the tumor, cross it, and reach all mouse organs. Electrophoretic analysis of the oligonucleotide extracted from tumor showed that the compounds were delivered in the tissue in the intact state.
摘要
Zotero 插件