Tsai W Y, Lee J S
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1994 Sep;93(9):810-2.
The purpose of this study was to evaluate the clinical application of serum insulin-like growth factor-I (IGF-I) levels for the workup of prepubertal children with short stature. IGF-I serum levels were measured by radioimmunoassay in 92 short prepubertal children (55 normal-short children, 18 dysmorphic-short children, and 19 children with classical growth hormone deficiency) and 105 normal prepubertal children. The serum IGF-I levels (mean +/- SEM) in these three groups of short children were 160 +/- 9 ng/ml, 188 +/- 16 ng/ml and 26 +/- 3 ng/ml, respectively. The mean serum IGF-I level for the 105 normal prepubertal children was 160 +/- 7 ng/ml. The mean serum IGF-I levels of the first two groups of short children were not significantly different from that of the prepubertal children with normal stature. On the other hand, the mean serum IGF-I level in children with classical growth hormone deficiency was significantly lower than those of the other two groups of short children and that of prepubertal children with normal stature. Our study shows that the determination of serum IGF-I levels is of clinical value in the evaluation of short prepubertal children.
本研究的目的是评估血清胰岛素样生长因子-I（IGF-I）水平在青春期前身材矮小儿童检查中的临床应用。采用放射免疫分析法测定了92例青春期前身材矮小儿童（55例正常身材矮小儿童、18例畸形身材矮小儿童和19例典型生长激素缺乏儿童）及105例正常青春期前儿童的IGF-I血清水平。这三组身材矮小儿童的血清IGF-I水平（均值±标准误）分别为160±9 ng/ml、188±16 ng/ml和26±3 ng/ml。105例正常青春期前儿童的血清IGF-I平均水平为160±7 ng/ml。前两组身材矮小儿童的血清IGF-I平均水平与正常青春期前儿童的水平无显著差异。另一方面，典型生长激素缺乏儿童的血清IGF-I平均水平显著低于其他两组身材矮小儿童及正常青春期前儿童的水平。我们的研究表明，测定血清IGF-I水平在评估青春期前身材矮小儿童方面具有临床价值。
