Tsai W Y, Fang L J, Lee J S
Department of Pediatrics, National Taiwan University Hospital, Taipei, R.O.C.
J Formos Med Assoc. 1993 Jul;92(7):614-7.
In order to establish the range of the serum insulin-like growth factor-I (IGF-I) concentrations for various ages in normal Chinese children and to evaluate the use of IGF-I levels in the diagnosis of classical growth hormone deficiency, the serum concentrations of IGF-I of 310 normal Chinese children (137 boys and 173 girls) and 13 children (10 boys and three girls) with classical growth hormone deficiency were determined. In this study, we divided normal subjects of each sex into five age groups. In both sexes, an increase in the mean IGF-I levels of normal children was statistically significant around the age of three and at the age corresponding to the onset of puberty. The mean IGF-I levels in the serum of girls were higher than those in boys at all ages. However, the differences were statistically significant only at 8-10 and 10-12 years of age. The serum IGF-I concentrations of 13 patients with classical growth hormone deficiency ranged from undetectable to 78 ng/mL, and all of their IGF-I levels were lower than the normal range for their age. Because of the low IGF-I concentrations in the serum of normal children younger than three years of age, its clinical application in this age group is limited. From this study, we conclude that the determination of serum IGF-I concentrations is of clinical value in the diagnosis of growth hormone deficiency in Chinese children over three years of age.
为建立中国正常儿童各年龄段血清胰岛素样生长因子-I（IGF-I）浓度范围，并评估IGF-I水平在经典生长激素缺乏症诊断中的应用，测定了310名中国正常儿童（137名男孩和173名女孩）及13名经典生长激素缺乏症患儿（10名男孩和3名女孩）的血清IGF-I浓度。本研究将各性别正常受试者分为五个年龄组。在男女两性中，正常儿童的平均IGF-I水平在三岁左右及青春期开始对应的年龄时升高具有统计学意义。各年龄段女孩血清中的平均IGF-I水平均高于男孩。然而，差异仅在8至10岁和10至12岁时具有统计学意义。13例经典生长激素缺乏症患者的血清IGF-I浓度范围为检测不到至78 ng/mL，其所有IGF-I水平均低于其年龄对应的正常范围。由于三岁以下正常儿童血清中IGF-I浓度较低，其在该年龄组的临床应用有限。从本研究中，我们得出结论，测定血清IGF-I浓度对三岁以上中国儿童生长激素缺乏症的诊断具有临床价值。
