重组HIV整合酶、RuvC和核糖核酸酶H的结构。
Recombining the structures of HIV integrase, RuvC and RNase H.
作者信息
Yang W, Steitz T A
机构信息
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06520, USA.
出版信息
Structure. 1995 Feb 15;3(2):131-4. doi: 10.1016/s0969-2126(01)00142-3.
PMID:7735828
Abstract
The recently reported crystal structures of two recombination enzymes, the catalytic domain of HIV integrase and Escherichia coli RuvC, an endonuclease, are surprisingly similar to that of ribonuclease H suggesting the possibility that they have a common enzymatic mechanism.
摘要
最近报道的两种重组酶的晶体结构，即HIV整合酶的催化结构域和一种核酸内切酶——大肠杆菌RuvC，与核糖核酸酶H的晶体结构惊人地相似，这表明它们可能具有共同的酶促机制。
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