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The interaction between halofenate and propranolol.

作者信息

Huffman D H, Azarnoff D L, Shoeman D W, Dujovne C A

出版信息

Clin Pharmacol Ther. 1976 Jun;19(6):807-12. doi: 10.1002/cpt1976196807.

DOI:10.1002/cpt1976196807
PMID:773588
Abstract

The effect of halofenate on beta adrenergic blockade by propranolol was studied in 4 subjects during chronic drug administration in a randomized, double-blind study. The plasma propranolol concentration was significantly lower during treatment with halofenate than with placebo. The reduction in propranolol levels correlated with a decrease in beta adrenergic blockade. The mechanism for the decrease in plasma concentration has not been determined.

摘要

相似文献

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