抗抑郁药对爪蟾卵泡包被卵母细胞中格列本脲敏感钾电流的抑制作用。
Inhibition by antidepressants of glibenclamide-sensitive K+ currents in follicle-enclosed Xenopus oocytes.
作者信息
Sakuta H
机构信息
Department of Pharmacology, National Defense Medical College, Saitama, Japan.
出版信息
Can J Physiol Pharmacol. 1994 Dec;72(12):1586-8. doi: 10.1139/y94-228.
DOI:10.1139/y94-228
PMID:7736352
Abstract
Effects of antidepressive drugs on glibenclamide-sensitive K+ currents were investigated using follicle-enclosed Xenopus oocytes. Antidepressive drugs, imipramine, desipramine, and amitriptyline, inhibited the K+ currents with IC50 (microM) values of 35.4, 39.7, and 87.7, respectively. The K+ current blocking actions of antidepressants appear to be associated with their local anesthetic related structures.
摘要
利用卵泡包被的非洲爪蟾卵母细胞研究了抗抑郁药对格列本脲敏感的钾电流的影响。抗抑郁药丙咪嗪、地昔帕明和阿米替林抑制钾电流，其IC50（微摩尔）值分别为35.4、39.7和87.7。抗抑郁药的钾电流阻断作用似乎与其局部麻醉相关结构有关。
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