β-胡萝卜素对可移植性小鼠淋巴瘤中生物转化酶活性模式和水平变化的作用

Role of beta-carotene on the changes in activity patterns and levels of biotransforming enzymes in transplantable murine lymphoma.

作者信息

Ghosh B, Sardar S, Roy K, Chatterjee M

机构信息

Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.

出版信息

Cancer Lett. 1995 Apr 14;90(2):191-7. doi: 10.1016/0304-3835(95)03711-5.

DOI:10.1016/0304-3835(95)03711-5

PMID:7736455

Abstract

The differential levels of induction of hepatic microsomal cytochrome P-450 (cyt. P-450), UDP-glucuronyl transferase (UDPGT) and cytosolic glutathione-S-transferase (GST) activities were evaluated over various periods of time, following tumor transplantation in male Swiss albino mice in the presence and absence of beta-carotene supplementation in their basal diet (100 mg/kg). An increase in the total hepatic microsomal cytochrome P-450 and UDP-glucuronyl transferase and cytosolic GSH-transferase activities (1.5 to 2 fold) occurred during the later stage of tumor progression (22 +/- 2 days onwards). However, beta-carotene supplementation throughout the study increased or decreased the random activity trends of the above markers significantly (P < 0.05- < 0.01). Finally, beta-carotene supplementation could enhance the survival of the host bearing lymphoma by almost 2-fold (50-60 days) over and above the lymphoma controls (30-35 days).

摘要

在雄性瑞士白化小鼠进行肿瘤移植后，于不同时间段评估肝微粒体细胞色素P - 450（细胞色素P - 450）、尿苷二磷酸葡萄糖醛酸基转移酶（UDPGT）和胞质谷胱甘肽 - S - 转移酶（GST）活性的诱导差异水平，基础饮食中添加（100毫克/千克）和不添加β - 胡萝卜素。在肿瘤进展后期（22±2天及以后），肝微粒体细胞色素P - 450、尿苷二磷酸葡萄糖醛酸基转移酶和胞质谷胱甘肽 - S - 转移酶的总活性增加（1.5至2倍）。然而，在整个研究过程中添加β - 胡萝卜素显著增加或降低了上述标志物的随机活性趋势（P < 0.05 - < 0.01）。最后，与淋巴瘤对照组（30 - 35天）相比，添加β - 胡萝卜素可使荷淋巴瘤宿主的生存期延长近2倍（50 - 60天）。