大鼠肾癌基因区域的显微切割文库。
A microdissection library of the rat renal carcinoma gene region.
作者信息
Bell D W, Yeung R S, Bohlander S K, Cheng J Q, Jin F, Testa J R
机构信息
Division of Medical Sciences, Fox Chase Cancer Center, Philadelphia, PA, USA.
出版信息
Cytogenet Cell Genet. 1995;70(1-2):92-4. doi: 10.1159/000133999.
PMID:7736798
Abstract
Predisposition to hereditary renal carcinoma in the Eker rat involves a mutation of a putative tumor suppressor gene within chromosome band 10q12. We describe the identification of three unique polymorphic sequences in the vicinity of this locus following the microdissection, construction and characterization of a region-specific DNA library for rat chromosome band 10q12.
摘要
埃克大鼠遗传性肾癌的易感性涉及位于染色体10q12带内一个假定的肿瘤抑制基因的突变。我们描述了在对大鼠染色体10q12带进行显微切割、构建区域特异性DNA文库并对其进行表征后，在该基因座附近鉴定出三个独特的多态性序列。
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