Wroński M
Oddziału Neurochirurgii Centrum Onkologii im. Sloana-Ketteringa w Nowym Jorku.
Chir Narzadow Ruchu Ortop Pol. 1995;60(1):55-60.
Brain metastases from sarcoma are rare, and data concerning the treatment and results of therapy are sparse. We retrospectively reviewed a series of 28 patients with brain metastases from sarcoma, who were neuro-surgically treated in single institution over 20 years. There were 15 men and 13 women. In 21 patients the brain lesion was located in the supratentorial region, and in 7 patients infratentorially. The median age at brain metastasis diagnosis was 25 years (range 2.6-68 years). Median time from primary diagnosis to diagnosis of brain metastasis was 26.7 months. Lung metastases were present in 21 patients (76%) (8 synchronous with the brain lesion). Pulmonary metastases were resected in 14 patients (50%). The overall median survival time from diagnosis of primary sarcoma was 38.8 months, and from craniotomy was 6.6 months. The presence or absence of lung lesion did not change the median survival calculated from diagnosis of brain metastasis (7 mos and 4.5 mos, respectively, p < 0.48, log-rank test). Two patients (7%) died within 30 days of operation. One-year survival was 36% and 2-year survival was 18%. Three patients (12%) survived over 5 years. Since brain metastases from sarcoma are refractory to alternative treatment, surgical excision is indicated when feasible. Brain metastases from sarcoma are uncommon and usually occur in association with or following lung metastasis. Long term survival is possible in a small percentage of patients.
肉瘤脑转移罕见，有关治疗及治疗结果的数据稀少。我们回顾性分析了一系列28例肉瘤脑转移患者，这些患者在单一机构接受了20余年的神经外科治疗。其中男性15例，女性13例。21例患者脑病灶位于幕上区域，7例位于幕下区域。脑转移诊断时的中位年龄为25岁（范围2.6 - 68岁）。从原发诊断到脑转移诊断的中位时间为26.7个月。21例患者（76%）存在肺转移（8例与脑病灶同时出现）。14例患者（50%）切除了肺转移灶。从原发肉瘤诊断开始计算的总体中位生存时间为38.8个月，开颅术后为6.6个月。有无肺部病灶并不改变从脑转移诊断计算出的中位生存时间（分别为7个月和4.5个月，p < 0.48，对数秩检验）。2例患者（7%）在术后30天内死亡。1年生存率为36%，2年生存率为18%。3例患者（12%）存活超过5年。由于肉瘤脑转移对其他治疗难治，可行时应行手术切除。肉瘤脑转移不常见，通常与肺转移同时发生或在肺转移之后出现。一小部分患者有可能长期存活。
