Makman M H, Dvorkin B, Stefano G B
Department of Biochemistry, Albert Einstein College of Medicine, New York, NY 10461, USA.
Eur J Pharmacol. 1995 Feb 6;273(3):R5-6. doi: 10.1016/0014-2999(95)00002-3.
Opiate alkaloid-selective, opioid peptide-insensitive mu 3 receptors are present in three murine macrophage cell lines (J774.2; RAW 264.7; BAC1.2F5). The receptor binds morphine, its active metabolite morphine 6-glucuronide and certain other alkaloids, but not morphine 3-glucuronide or any of the opioid peptides tested. The cell lines thus provide valuable model systems for investigation of mu 3-opiate receptors, previously demonstrated to mediate inhibitory effects of morphine on activation of human peripheral blood macrophages (monocytes).
阿片生物碱选择性、对阿片肽不敏感的μ3受体存在于三种小鼠巨噬细胞系（J774.2；RAW 264.7；BAC1.2F5）中。该受体可结合吗啡、其活性代谢物吗啡6-葡萄糖醛酸苷及某些其他生物碱，但不结合吗啡3-葡萄糖醛酸苷或所测试的任何阿片肽。因此，这些细胞系为研究μ3阿片受体提供了有价值的模型系统，先前已证明该受体可介导吗啡对人外周血巨噬细胞（单核细胞）激活的抑制作用。
