Freed K A, Aitken M A, Brennecke S P, Rice G E
Department of Perinatal Medicine, Royal Women's Hospital, Carlton, Vic., Australia.
Gynecol Obstet Invest. 1995;39(2):73-8. doi: 10.1159/000292383.
The aim of this study was to determine the relative abundance of prostaglandin G/H synthase-1 (PGHS-1) mRNA in human amnion, choriodecidua and placenta obtained before (n = 5), during (n = 5) and after spontaneous-onset labour and delivery at term (n = 5). PGHS-1 mRNA relative abundance was not affected by labour status (p > 0.1) nor differently expressed between gestational tissues (p > 0.05). These data are consistent with the hypothesis that PGHS-1 is a constitutively expressed isozyme and that an increase in the relative abundance of mRNA encoding this enzyme is not necessary for the labour-associated increase in prostaglandin formation.
本研究的目的是确定在足月自然发动分娩前（n = 5）、分娩期间（n = 5）和分娩后（n = 5）获取的人羊膜、绒毛蜕膜和胎盘中前列腺素G/H合酶-1（PGHS-1）mRNA的相对丰度。PGHS-1 mRNA的相对丰度不受分娩状态的影响（p > 0.1），在不同妊娠组织之间也没有差异表达（p > 0.05）。这些数据与以下假设一致：PGHS-1是一种组成型表达的同工酶，并且编码该酶的mRNA相对丰度增加对于分娩相关的前列腺素形成增加并非必要。
