Biology of hypothalamic neurons and pituitary cells.

Results obtained by examining hypothalamic neurons producing precursors to neurohormones, and pituitary cells synthesizing peptide and glycoprotein families of hormones, and recent advances in comparative endocrinology, have been summarized and considered from the following viewpoints: species specificity in the organization and communication of the hypothalamic neurons with different brain areas lying inside the BBB and with CVOs; sensitivity of hypothalamic neurons and pituitary cells to the environmental stimuli; gonadal steroids as modulators of gene expression needed for neuronal differentiation and synaptogenesis; dose(s)-dependent pituitary cell proliferation and differentiation; an inverse relationship between PRL and GH synthesis and release and also between degree of hyperplasia and hypertrophy of PRL cells and retardation of GTH cell differentiation; and responsiveness of neurons producing CRH, and of neurons and pituitary cells synthesizing POMC hormones, to stress and glucocorticosteroids. These data show that growth of the animals may be stimulated, retarded, or inhibited; reproductive properties and behavior may be under hormonal control; and character of responsiveness in reaction to stress, and ability for adaptation and other related functions, may be controlled.