黑腹果蝇在饥饿期间会将乙醇用作能量来源吗？

Does Drosophila melanogaster use ethanol as an energy source during starvation?

作者信息

Pecsenye K, Lefkovitch L P, Giles B E, Saura A

机构信息

Department of Genetics, University of Umeå, Sweden.

出版信息

Hereditas. 1994;121(3):225-36. doi: 10.1111/j.1601-5223.1994.t01-1-00225.x.

DOI:10.1111/j.1601-5223.1994.t01-1-00225.x

PMID:7737885

Abstract

The influence of starvation on activities of three enzymes (ADH, ODH and alpha GPDH) was studied in Drosophila melanogaster. The changes were compared in two inbred lines which had different allelic combinations at the Odh and Aldox loci. We also studied the effect of ethanol on media which contained no sucrose ("starvation conditions"). The results show that there are large differences in the larval and adult alcohol utilization. The alcohol content of the medium, in the absence of sugar, appeared to be toxic for the larvae, while the adults appeared to utilize it as an energy source. The two strains differed little in their responses to starvation or to the ethanol treatment applied under starvation conditions. We conclude that the degree of toxicity of ethanol is highly dependent on the presence of sucrose.

摘要

研究了饥饿对黑腹果蝇三种酶（乙醇脱氢酶、苹果酸脱氢酶和α-甘油磷酸脱氢酶）活性的影响。比较了两个在苹果酸脱氢酶和醛氧化酶基因座具有不同等位基因组合的近交系中的变化。我们还研究了乙醇对不含蔗糖的培养基（“饥饿条件”）的影响。结果表明，幼虫和成虫对酒精的利用存在很大差异。在无糖的情况下，培养基中的酒精含量对幼虫似乎有毒，而成虫似乎将其作为能量来源利用。这两个品系对饥饿或饥饿条件下施加的乙醇处理的反应差异不大。我们得出结论，乙醇的毒性程度高度依赖于蔗糖的存在。