Allaire C, Trinquand C, Nordmann J P, Dascotte J C, George J L, Lesure P, Rouland J F, Khaitrine L, Sirbat D
Laboratoire Chauvin, Montpellier.
J Fr Ophtalmol. 1995;18(1):22-6.
The aim of the study was to compare 2 beta-blocker eye drops at a low concentration: 0.5% carteolol and 0.1% timolol.
The study was designed as a random-order, double-blinded comparison of 2 parallel treatment groups. Fifty patients with early primary open angle glaucoma or high intraocular pressure were included. The treatment lasted 4 weeks, on the basis of 1 drop twice daily. Diurnal I.O.P. curve was assessed with 4 measurements from 8.30 a.m. to 4.30 p.m. before and after treatment. The 8.30 a.m. measure of the final assessment of I.O.P. curve was established prior to morning medication. The mean values of the 4 measures were compared.
Both treatments reduced IOP by a comparable amount: 4.25 +/- 1.2 mmHg (mean +/- SD) for carteolol and 4.69 +/- 1.9 mmHg for timolol. The decrease of IOP was found at every time of assessment, without any significant difference between treatments. Both eye drops were very well tolerated.
The results of this study show that the new beta-blocker eye drop solution 0.5% carteolol is effective for initial management of high intraocular pressure.
本研究旨在比较两种低浓度的β受体阻滞剂滴眼液：0.5%的卡替洛尔和0.1%的噻吗洛尔。
本研究设计为对两个平行治疗组进行随机顺序、双盲比较。纳入了50例早期原发性开角型青光眼或高眼压患者。治疗持续4周，每天两次，每次一滴。在治疗前后，于上午8:30至下午4:30期间进行4次测量来评估日间眼压曲线。眼压曲线最终评估的上午8:30测量值是在早晨用药前确定的。比较这4次测量的平均值。
两种治疗方法降低眼压的幅度相当：卡替洛尔为4.25±1.2 mmHg（平均值±标准差），噻吗洛尔为4.69±1.9 mmHg。在每次评估时均发现眼压下降，两种治疗方法之间无显著差异。两种滴眼液的耐受性都很好。
本研究结果表明，新的β受体阻滞剂滴眼液0.5%卡替洛尔对高眼压的初始治疗有效。
