多发性硬化症生存的预后因素：挪威默勒-鲁姆斯达尔郡基于人群的纵向研究。
Prognostic factors for survival in multiple sclerosis: a longitudinal, population based study in Møre and Romsdal, Norway.
作者信息
Midgard R, Albrektsen G, Riise T, Kvåle G, Nyland H
机构信息
Department of Neurology, Molde Hospital, Norway.
出版信息
J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):417-21. doi: 10.1136/jnnp.58.4.417.
Abstract
A longitudinal, population based study of life expectancy in multiple sclerosis was performed in the county of Møre and Romsdal, Norway during the period 1950-84. A total of 251 patients with multiple sclerosis (110 men, 141 women, mean age at onset of disease 33.6 years) were included. The mean follow up time was 18.1 years. At the end of the study period 70 patients had died. Fifty four (77.1%) of these had multiple sclerosis as the underlying or contributing cause of death on the death certificates. Young age at onset, initial remitting clinical course, and the presence of sensory symptoms at onset were significantly associated with longer survival.
摘要
1950年至1984年期间，在挪威默勒-鲁姆斯达尔郡开展了一项基于人群的多发性硬化症预期寿命纵向研究。共纳入251例多发性硬化症患者（110名男性，141名女性，疾病发病时的平均年龄为33.6岁）。平均随访时间为18.1年。研究期末，70例患者死亡。其中54例（77.1%）在死亡证明上的根本死因或促成死因是多发性硬化症。发病时年龄较小、初始临床病程呈缓解型以及发病时存在感觉症状与更长的生存期显著相关。
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