Nashef L, Fish D R, Sander J W, Shorvon S D
University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
J Neurol Neurosurg Psychiatry. 1995 Apr;58(4):462-4. doi: 10.1136/jnnp.58.4.462.
Overall mortality, incidence of sudden unexpected death, and cause of death were determined in 601 adult outpatients with epilepsy at a tertiary referral centre. The patients were followed up from 1990 to 30 June 1993. There were 24 deaths among the 601 patients (1849 patient years) with a standardised mortality ratio of 5.1 (95% confidence interval 3.3-7.6) of which 14 were related to epilepsy. Underlying disease of which epilepsy was a symptom accounted for four deaths only. An incidence of sudden deaths (including seizure related) was of the order of 1:200/year. In conclusion, excess mortality in chronic epilepsy is more likely to be related to the epilepsy itself than to underlying pathology. The relatively high incidence of sudden deaths found in this hospital based cohort has important implications for patient management.
在一家三级转诊中心，对601例成年癫痫门诊患者的总体死亡率、意外猝死发生率及死因进行了测定。这些患者从1990年开始随访至1993年6月30日。601例患者（1849患者年）中有24例死亡，标准化死亡率为5.1（95%置信区间3.3 - 7.6），其中14例与癫痫相关。仅作为症状的潜在疾病导致4例死亡。猝死（包括与癫痫发作相关的）发生率约为每年1:200。总之，慢性癫痫患者的额外死亡率更可能与癫痫本身有关，而非潜在病理状况。在这个基于医院的队列中发现的相对较高的猝死发生率对患者管理具有重要意义。
