Elgazzar A H, Munda R, Fernandez-Ulloa M, Clark J, Ryan J R, Hughes J A
Department of Radiology, University of Cincinnati Hospital, Ohio, USA.
J Nucl Med. 1995 May;36(5):771-7.
The purpose of this study was to evaluate the feasibility of using 99mTc-sestamibi in the assessment of pancreatic transplant.
Ten transplant recipients with a history of insulin-dependent diabetes mellitus were studied. Fourteen 99mTc-sestamibi studies were performed. Each patient was injected intravenously with 10 mCi of 99mTc-sestamibi. Two-second frames were obtained for 1 min, followed by serial dynamic and static images every 5 min for 30 min. Technetium-99m sestamibi studies, read by two nuclear medicine physicians, were correlated with clinicopathologic findings and compared to the ten 201Tl studies obtained in seven of these patients.
On 99mTc-sestamibi images, normally functioning grafts showed adequate perfusion on the angiogram and good uptake followed by clearance on static images. Time-activity curves showed an initial upslope followed by a downslope after the initial uptake peak. The quality of 99mTc-sestamibi images was superior to those of 201Tl in five, similar in four and marginally inferior in one paired study. Technetium-99m-sestamibi was used for both flow and static images, whereas a 99mTc radiotracer angiogram was needed to accompany the 201Tl study.
Our preliminary experience indicates that 99mTc-sestamibi helps evaluate pancreatic transplants and provides high count statistics, which result in better image quality and diagnostic detail. Extensive quantitative studies are being performed to further evaluate this agent's role in the clinical management of pancreatic transplant patients.
本研究的目的是评估99mTc-司他米比在胰腺移植评估中的可行性。
对10例有胰岛素依赖型糖尿病病史的移植受者进行研究。共进行了14次99mTc-司他米比检查。每位患者静脉注射10mCi的99mTc-司他米比。先采集2秒的图像，持续1分钟，随后每5分钟进行系列动态和静态图像采集，共30分钟。由两名核医学医师解读99mTc-司他米比检查结果，并与临床病理结果进行关联，同时与其中7例患者进行的10次201Tl检查结果进行比较。
在99mTc-司他米比图像上，功能正常的移植物在血管造影上显示灌注良好，静态图像上摄取良好随后清除。时间-活性曲线显示在初始摄取峰值后先有上升斜率，随后有下降斜率。在一项配对研究中，99mTc-司他米比图像质量在5例中优于201Tl图像，4例相似，1例略差。99mTc-司他米比用于血流和静态图像，而201Tl检查需要同时进行99mTc放射性示踪剂血管造影。
我们的初步经验表明，99mTc-司他米比有助于评估胰腺移植，并提供高计数统计，从而产生更好的图像质量和诊断细节。正在进行广泛的定量研究，以进一步评估该药物在胰腺移植患者临床管理中的作用。
