Uchisako H, Suga K, Tanaka N, Nishigauchi K, Matsumoto T, Matsunaga N, Nakanishi T
Department of Radiology, Yamaguchi University School of Medicine, Ube, Japan.
J Nucl Med. 1995 May;36(5):822-5.
Hypertrophic osteoarthropathy was detected in a 55-yr-old man with pulmonary squamous-cell cancer by bone scintigraphy using 99mTc-hydroxy methylene diphosphonate (HMDP). Intense symmetrical uptake was demonstrated in the distal portions of the long bones as was the parallel tract sign, accompanied by markedly elevated serum growth hormone levels. After chemoradiotherapy for pulmonary cancer, the arthralgia disappeared and scintigraphic findings and serum growth hormone levels improved, suggesting that ectopic production of growth hormone in the pulmonary tumor had been associated with hypertrophic osteoarthropathy. These findings indicate that bone scintigraphy is useful for detecting hypertrophic osteoarthropathy, and assessing alterations in hypertrophic osteoarthropathy activity post-treatment.
一名55岁肺鳞状细胞癌男性患者，通过使用99mTc-羟亚甲基二膦酸盐（HMDP）进行骨闪烁扫描检测到肥大性骨关节病。长骨远端出现强烈对称摄取及平行束征，同时血清生长激素水平显著升高。肺癌放化疗后，关节痛消失，闪烁扫描结果及血清生长激素水平改善，提示肺部肿瘤异位分泌生长激素与肥大性骨关节病有关。这些发现表明，骨闪烁扫描对于检测肥大性骨关节病以及评估治疗后肥大性骨关节病活动的变化很有用。
