Tamura A, Ohata C, Hirakakiuchi Y, Sato T
Graduate School of Health Science, Chukyo Women's University, Aichi, Japan.
Yakugaku Zasshi. 1995 Mar;115(3):250-5. doi: 10.1248/yakushi1947.115.3_250.
Suppressive effects of several iodinated contrast media on stimulus-induced aggregation of human platelets were demonstrated. All contrast media, including ionic (iothalamate and ioxaglate) and non-ionic ones (iohexol, ioversol and iopamidol), suppressed the collagen- and thrombin-induced aggregation in a concentration-dependent manner. The effects of the former were much stronger than those of the latter. With ioxaglate, a similar inhibitory effect was also observed on PAF- and U46619-stimulated aggregation. The suppressive effect of ioxaglate on collagen-stimulated aggregation almost disappeared upon dilution of the medium with the platelet-poor plasma, suggesting that the effect is reversible.
已证实几种碘化造影剂对刺激诱导的人血小板聚集具有抑制作用。所有造影剂，包括离子型（碘他拉酸盐和碘克沙酸盐）和非离子型（碘海醇、碘佛醇和碘帕醇），均以浓度依赖的方式抑制胶原和凝血酶诱导的聚集。前者的作用比后者强得多。对于碘克沙酸盐，在PAF和U46619刺激的聚集中也观察到类似的抑制作用。用乏血小板血浆稀释培养基后，碘克沙酸盐对胶原刺激的聚集的抑制作用几乎消失，这表明该作用是可逆的。
