Honma A, Yamagishi M, Koba H, Abe S
Third Department of Internal Medicine, Sapporo Medical University, School of Medicine.
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Mar;33(3):282-92.
The distribution of centrilobular emphysematous lesions in the transverse plane was studied with high-resolution CT (HRCT) images of inflated and fixed lungs obtained from 49 patients with centrilobular emphysema (CLE). The transaxial distribution of low attenuation areas (LAA) was assessed quantitatively on HRCT images obtained from 21 patients. LAA in the outer layer accounted for a significantly lower ratio of the lung parenchyma than did those in the inner layer. Macroscopic analysis of 31 lobes obtained from 28 patients with CLE was done by point counting. The inner layer had many more LAA than the outer layer. Bronchiolar lesions were examined under the microscope for their relation to the observed variations in distribution in CLE. No significant differences were found in the bronchiolar lesions between the inner and outer layers. These data show a characteristic distribution pattern of CLE in the transverse plane. They also suggest that the disparity in distribution of LAA between the inner and outer layers is not influenced by the grade of bronchiolar pathological lesions.
利用从49例小叶中心型肺气肿（CLE）患者获取的充气及固定肺脏的高分辨率CT（HRCT）图像，研究了小叶中心型肺气肿病变在横断面上的分布情况。对21例患者的HRCT图像进行定量评估，分析低衰减区（LAA）的轴向分布。外层的LAA占肺实质的比例显著低于内层。对28例CLE患者的31个肺叶进行了宏观分析，采用点计数法。内层的LAA比外层多得多。在显微镜下检查细支气管病变与CLE中观察到的分布变化之间的关系。内层和外层的细支气管病变未发现显著差异。这些数据显示了CLE在横断面上的特征性分布模式。它们还表明，内层和外层LAA分布的差异不受细支气管病理病变程度的影响。
