小鼠大脑血清素浓度与Y染色体性别特异性部分之间的联系。
Linkage between brain serotonin concentration and the sex-specific part of the Y-chromosome in mice.
作者信息
Tordjman S, Roubertoux P L, Carlier M, Moutier R, Anderson G, Launay M, Degrelle H
机构信息
URA CNRS 1294, Université Paris V-René Descartes, France.
出版信息
Neurosci Lett. 1995 Jan 9;183(3):190-2. doi: 10.1016/0304-3940(94)11148-c.
The implication of the sex-specific part of the Y-chromosome (YS-SP) on brain serotonin (5-HT) level was investigated using congenic strains for this chromosomal region. The 5-HT level, which was higher in the NZB than in the CBA/H strain of mice, was depleted by the transfer of the YS-SP from NZB on CBA/H whereas the transfer of the YS-SP from CBA/H on NZB had no effect. The variations of 5-HT levels were not correlated with plasma testosterone concentration which is also dependent of the YS-SP.
利用该染色体区域的近交系研究了Y染色体性别特异性部分（YS-SP）对脑血清素（5-HT）水平的影响。在小鼠中，NZB品系的5-HT水平高于CBA/H品系，将NZB的YS-SP转移到CBA/H品系时，5-HT水平降低，而将CBA/H的YS-SP转移到NZB品系则没有影响。5-HT水平的变化与同样依赖于YS-SP的血浆睾酮浓度无关。
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